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Assessment of the Genetic Variation in Bone Fracture Healing

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Annual rept. 1 Oct 2003-30 Sep 2004

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The hypothesis of these studies is that the genomic processes that lead to the variations in both structural and material properties of bone development will be recapitulated in the developmental mechanisms that controls the bones structural geometry and material properties during fracture healing. Two goals were set out in the proposal to test this hypothesis. The first was to determine how variations in basic bone structure and material properties in three in bred strains of mice is translated into the healing process of fracture repair in terms of callus structure and biomechanical properties. Towards this goal microCT analysis of day 21 and 35 fracture calluses have been carried out and each strain showed unique variations in geometric structure. The second goal of these studies was directed at identifying the underlying genomic processes that are activated and accompany fracture healing in the three genetic strains of mice through the use of full transcriptional profiling of gene expression over the fracture healing period. Towards completion of this goal an initial transcriptional profiling study in one of three strains B6 has been completed which both establishes our basic methodological approach to these studies and identifies several unique families of genes that are activated during fracture healing.

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  • Anatomy and Physiology
  • Medicine and Medical Research

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