Accession Number:

ADA429731

Title:

Magnetic Nanoparticles for Manipulation and Control of Biological Processes

Descriptive Note:

Final rept. Oct 2001-May 2004

Corporate Author:

MARYLAND UNIV COLLEGE PARK DEPT OF MATERIALS SCIENCE AND ENGINEERING

Report Date:

2004-05-01

Pagination or Media Count:

5.0

Abstract:

We explored the potential of magnetic nanoparticles MNPs for manipulation and control of cell functions using magnetic fields. We synthesized several types of MNPs, functionalize their surfaces to make them biocompatible, and bind them to cells. The investigation then focused on two phenomena, magnetoporation and AC magnetic field heating. In the magnetoporation experiments, we applied pulses of a magnetic field gradient to briefly open cell membranes. In the AC magnetic field heating experiments, we raised the local temperature via excitation of the MNPs chosen to maximize dissipative losses, and monitor the effect on cell viability.

Subject Categories:

  • Biology
  • Anatomy and Physiology
  • Electricity and Magnetism

Distribution Statement:

APPROVED FOR PUBLIC RELEASE