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Monitoring of Breast Tumor Response to Local Chemotherapeutic Agent Delivered by Biodegradable Fibers

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Annual rept. 1 May 2003-30 Apr 2004

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The goal of this research project is to investigate the possibilities of using NIRS to monitor the effects of chemotherapy and to reduce the side effects of chemotherapy by delivering the chemotherapeutic agent locally into the tumor. High dose of cyclophosphamide was administered to the rat through i.p. injection, and rat body weight and tumor volume were measured before and after administration of cyclophosphamide. The rat was given gas intervention from air to oxygen, and the dynamic changes of HbO2, Hb, and Hbtotal were measured in real time during the experiments. I have compared the simultaneously measured hemodynamic changes from four different locations of the tumor and shown intratumoral heterogeneity in tumor vascular structure. Hemodynamic parameters obtained by fitting the measured data with our hemodynamic model was compared between before and after cyclophosphamide administration, and it was found that destruction of tumor occurs much faster in the well perfused region than in the poorly perfused region. In addition, decrease in maximum of deltaHbO2 during oxygen intervention was also observed after chemotherapy. All the results support that we can apply NIRS to monitor the efficacy of cancer treatment such as radiation therapy, photodynamic therapy, and chemotherapy.

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  • Anatomy and Physiology
  • Medicine and Medical Research
  • Pharmacology
  • Atomic and Molecular Physics and Spectroscopy

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