Post-Renal Transplant Thrombotic Thrombocytopenic Purpura (TTP): Attributable to Immunosuppression or Graft Rejection? Report of Three Cases and Literature Review
YALE UNIV NEW HAVEN CT SCHOOL OF MEDICINE
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The immunomodulatory drug FK-506 Tacrolimus is a calcineurin inhibitor that, as such, indirectly inhibits the transcription of a gene encoding interleukin 2, a cytokine that is vital to the immune response process. Since its introduction in 1987, sporadic reports have appeared describing the development of thrombotic thrombocytopenic purpura TTP - or a similar syndrome - in patients taking this drug. Sirolimus Rapamune is another immunomodulatory drug with a more favorable side-effects profile than calcineurin inhibitors.
- Anatomy and Physiology
- Medicine and Medical Research