Accession Number:

ADA429590

Title:

Evaluation of Chronic Stress Induced Neurodegeneration and Treatment Using an In-vivo Retinal Model

Descriptive Note:

Final rept. 1 May 2001-30 Sep 2004

Corporate Author:

NAVAL HEALTH RESEARCH CENTER BROOKS CITY-BASE TX BROOKS DETACHMENT

Personal Author(s):

Report Date:

2004-09-01

Pagination or Media Count:

31.0

Abstract:

The objective of this project is to develop an in vivo damage model for the study of the mechanisms underlying retinal injuries and other neurodegenerative disorders. For this purpose the small snake eye with its unique suite of ocular properties, combined with the imaging capabilities of the confocal Scanning Laser Ophthalmoscope model was selected. Progress has been made in three areas of research necessary to establish the snake eye as a model for human neural injurydisease 1 Morphology Photochemical lesions are difficult to produce, are visible primarily at 24-hrs post-exposure, and therefore leave no experimental end point to be improved by treatment 2 Electrophysiology The functional characteristics of the pattern-evoked electroretinogram PERG recorded from the normal rat snake eye have been documented, and initial experiments with laser exposures indicate that the PERG is capable of tracking laser-induced changes in retinal function and 3 Immunohistochemical analyses Further evidence has been documented that the rat snake has an all cone retina. Immunohistochemical methods provide an additional tool for identifying key proteins released in response to neural injury.

Subject Categories:

  • Medicine and Medical Research
  • Medical Facilities, Equipment and Supplies

Distribution Statement:

APPROVED FOR PUBLIC RELEASE