Temperature-Responsive Polymers for Biological Applications
PENNSYLVANIA STATE UNIV UNIVERSITY PARK
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Water soluble polymers with tunable lower critical solution temperature LCST are of increasing interest for biological applications such as cell patterning, smart drug release, DNA sequencing etc. The present study addresses control of the polymer temperature response in water by varying chemical composition of the monomer. In order to achieve this a series of polymers were designed and synthesized based on an ethyleneoxideethylene monomer EOEE. Polymers were synthesized using polycondensation reactions of difunctional m-EO and n-EE oligomers. The cloud point follows linearly the balance of hydrophobichydrophilic interaction and can be tailored in the range of 7 - 700C by varying the mn composition and polymer type. Polymer grafting onto the silicon surface exhibits similar solubility behaviour. Adhesion energy measurements show that grafted polymers have solubility cloud points at the temperatures that are close to the ones of the bulk polymer solutions.
- Inorganic Chemistry
- Polymer Chemistry