Biodegradable-co-bioresponsive Hydrogels for Controlled Release of Growth Factor
PENNSYLVANIA STATE UNIV HERSHEY
Pagination or Media Count:
A series of multi-functional hydrogel systems have been designed and synthesized for potential brain implantation to realize controlled and sustained release of Nerve Growth Factor NGF for the treatment of Alzheimers disease AD. The systems are three-dimensional crosslinked copolymers composed of a thermo-responsive unit, a hydrolytically degradable and hydrophobic unit, and an enzymatically degradable and hydrophilic unit. They combine the merits of thermo-responsive and biodegradable polymeric drug delivery systems, and allow a low-temperature aqueous NGF loading to prevent protein denaturation. The hydrogels show a lower critical solution temperature LCST at approximately 32 oC, and demonstrate different swelling and release profiles at temperatures above 37 oC and below 25 oC the LCST.
- Medicine and Medical Research
- Organic Chemistry