Bone Growth, Mechanical Stimulus and IGF-I
Annual rept. 10 Sep 2003-10 Sep 2004
CHILDREN'S HOSPITAL LOS ANGELES CA
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Available data indicate that the genetic susceptibility for low bone mass is present very early in life. The aim of this project is to establish whether bone acquisition in teenagers who have sustained a fracture and have low bone mass can be enhanced by changing environmental factors, such as mechanical loading. The effects of two twelve-month interventions on musculoskeletal development will be studied and the results will be compared to matched teenagers undergoing no intervention. This study also examines the possible relations between the cross-sectional properties of bone and circulating levels of IGF-I, lGF-binding protein-3, and IGF-I genotypes, and between bone acquisition induced by interventions and insulin-like growth factors, in teenagers ages 15 to 20 years old. The cross-sectional arm of this project was successfully completed in 144 females and 144 males in August, 2004. Twenty-four females have completed the vibration intervention and calcium intake for one year, 24 female controls have completed the calcium intake for one year, and 24 females are currently being enrolled in the physical exercise intervention. Of the 144 males, 72 are currently being enrolled in the vibration intervention, as controls, or in the exercise intervention for one year.
- Medicine and Medical Research