Georgetown Institute for Cognitive and Computational Sciences
Final rept. 1 Apr 2001-31 Mar 2004, phase 3
GEORGETOWN UNIV WASHINGTON DC MEDICAL CENTER
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Understanding and modifying plasticityrecovery within the central nervous system CNS represents the over-arching theme of this multidisciplinary research program. Participating investigators have used tools from cellular and molecular neurobiology, as well as systems neuroscience, to study mechanisms of neuronal cell death, as well as plasticity, after acute or chronic CNS injury. This included developmentevaluation of pharmacological strategies to limit tissue damage and enhance recovery after acute or chronic neurodegeneration. Magnetic resonance imaging and spectroscopy were utilized as tools to evaluate changes in response to injury andor treatment. Computational modeling was also used to predict both plasticity and for drug discovery. Together, these complementary research efforts were intended to elucidate mechanismsprocesses relating to CNS injury and plasticity, with particular reference to language disorders, traumatic brain injury, spinal cord injury, and Alzheimers disease.
- Anatomy and Physiology
- Medicine and Medical Research
- Atomic and Molecular Physics and Spectroscopy