Syntheses and Characterizations of Smart and Biodegradable Dendritic Nanoparticles for Controlled Drug Delivery
PENNSYLVANIA STATE UNIV UNIVERSITY PARK
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In order to transport therapeutic agents across blood brain barrier BBB for sustained time in response to biological need we designed and synthesized novel dendritic nanoparticles with thermoresponsive and biodegradable properties as drug delivery systems. The nano-sized dendrimer was prepared by coupling reaction of polyL-lysine PLL dendron and polyN- isopropylacrylamide PNIPAAM grafted with polyL-lactic acid PLLA. The chemical structure and molar mass of the dendrimer was characterized and confirmed by fourier transform infrared spectroscopy FTIR and matrix assisted laser desorptionionization time of flight mass spectroscopy MALDI-TOF. The dendrimer was responsive to temperature changes by showing lower critical solution temperature LCST measured by UV-VIS spectroscopy. The LCST depended on the concentrations of the dendrimer. The dendrimer also demonstrated biodegradable properties with decreasing their molar mass as a function of time.
- Medicine and Medical Research
- Numerical Mathematics
- Atomic and Molecular Physics and Spectroscopy