Accession Number:

ADA429281

Title:

Syntheses and Characterizations of Smart and Biodegradable Dendritic Nanoparticles for Controlled Drug Delivery

Descriptive Note:

Conference paper

Corporate Author:

PENNSYLVANIA STATE UNIV UNIVERSITY PARK

Personal Author(s):

Report Date:

2003-06-01

Pagination or Media Count:

6.0

Abstract:

In order to transport therapeutic agents across blood brain barrier BBB for sustained time in response to biological need we designed and synthesized novel dendritic nanoparticles with thermoresponsive and biodegradable properties as drug delivery systems. The nano-sized dendrimer was prepared by coupling reaction of polyL-lysine PLL dendron and polyN- isopropylacrylamide PNIPAAM grafted with polyL-lactic acid PLLA. The chemical structure and molar mass of the dendrimer was characterized and confirmed by fourier transform infrared spectroscopy FTIR and matrix assisted laser desorptionionization time of flight mass spectroscopy MALDI-TOF. The dendrimer was responsive to temperature changes by showing lower critical solution temperature LCST measured by UV-VIS spectroscopy. The LCST depended on the concentrations of the dendrimer. The dendrimer also demonstrated biodegradable properties with decreasing their molar mass as a function of time.

Subject Categories:

  • Medicine and Medical Research
  • Numerical Mathematics
  • Atomic and Molecular Physics and Spectroscopy

Distribution Statement:

APPROVED FOR PUBLIC RELEASE