Accession Number:

ADA429279

Title:

Replacing the Nucleobases in DNA with Designer Molecules

Descriptive Note:

Journal article

Corporate Author:

STANFORD UNIV CA DEPT OF CHEMISTRY

Personal Author(s):

Report Date:

2003-07-26

Pagination or Media Count:

9.0

Abstract:

DNA is not only a carrier of genetic information, but it is also a versatile supramolecular scaffold, arranging smaller organic structures into predesigned geometries. Herein are discussed molecular strategies in which the natural DNA bases on the sugar-phosphate backbone are replaced by other molecules. Some of the base replacements under study include fluorophores, ligands for metals, helix stabilizers, and DNA base shape mimics.

Subject Categories:

  • Biochemistry
  • Organic Chemistry
  • Optics

Distribution Statement:

APPROVED FOR PUBLIC RELEASE