Accession Number:

ADA429260

Title:

An Epigenetic Approach to Breast Cancer Treatment

Descriptive Note:

Final rept.

Corporate Author:

CALIFORNIA UNIV SANTA BARBARA DEPT OF CHEMISTRY AND BIOCHEMISTRY

Personal Author(s):

Report Date:

2003-08-01

Pagination or Media Count:

67.0

Abstract:

DNA methylation is an epigenetic process that leads to normal and dysfunctional gene regulation. The latter is a well-documented pathway to tumorigenesis, particularly for certain tumors, such as those involved in breast cancer. We have identified several inhibitors of the mammalian DNA cytosine methyltransferase, and are trying to determine if such compounds are suitable for further development as cancer therapies.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE