Molecular Genetic and Gene Therapy Studies of the Musculoskeletal System
LOMA LINDA VETERANS ASSOCIATION FOR RESEARCH AND EDUCATION CA
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The primary goal of the proposed work is to apply several state of the art molecular genetic and gene therapy technologies to address fundamental questions in bone biology with a particular emphasis on attempting lto clarify gene functions of the those genes that are involved in the musculoskeletal system and 2to promote rapid healing and eventually regeneration of soft and hared tissues using appropriate animal models. To discover novel genes and evaluated functional genes relevant to the musculoskeletal system, we are performing a number of molecular genetics studies using appropriate mouse models. To develop therapeutic approaches for treating systemic and local lesions in the skeleton by means of gene therapy, we are developing technologies 0 target one or more growth factor genes to bone using experimental animal model systems. During the last funding period, we have successfully accomplished all of the specific objectives. Our work during this period has resulted in 2 manuscripts and 3 abstracts. We believe that successful accomplishment of the proposed studies will provide a better understanding of the molecular mechanics involved in soft and hard tissue regeneration and will provide a frame work for future development of therapies for soft and hard tissue injuries.
- Genetic Engineering and Molecular Biology