Long Term Outcomes of BRCA1/BRCA2 Mutation Testing
Annual rept. 21 Jul 2003-20 Jul 2004
GEORGETOWN UNIV WASHINGTON DC
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This project aims to gain a better understanding of the implications of genetic testing for breast-ovarian cancer susceptibility. The primary goal is to evaluate the impact of BRACA1BRACA2 mutation testing on long term psychosocial quality of life, distress, social functioning and preventionsurveillance mammography, cAl25, transvaginal ultrasound, prophylactic mastectomy, prophylactic oophorectomy and chemoprevention outcomes. To accomplish this we will measure outcomes within a group of women who received BRCAlBRACA2 test results at least four years ago. We will divide our sample based upon their personal cancer history evaluating cancer survivors with different measures compared to unaffected individuals. For both survivors and unaffected individuals we will recruit separate comparison samples of women who have never received BRCAlBRACA2 testing. To date, we have submitted a protocol and received IRB approval from Georgetown University, have submitted a protocol and are awaiting approval from the DOD, have developed our measurement and data management systems and are prepared to begin accrual upon receipt of human subjects approval from the DOD.
- Medicine and Medical Research