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Estrogen Metabolism and Prostate Cancer Risk: A Prospective Study
Annual rept. 1 May 2003-30 Apr 2004
STATE UNIV OF NEW YORK AT ALBANY
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There is experimental evidence showing that a sedentary life-style and high fat diet induce estrogen metabolism toward 1 6 alpha hydroxylation leading to biologically potent metabolites estriol and 16 alpha hydroxyestrone. An active life-style and a low fat diet induce the alternative 2-hydroxylation with production of weak estrogen metabolites 2-hydroxyestrone. Potent estrogens may increase prostate cell division and increase prostate cancer risk. The research hypothesis is that the preferential induction of the 16 alpha hydroxylation pathway in respect to the 2-hydroxylation, is associated with an increase risk of prostate cancer. We conduct a nested case-control study within the cohort of Western New York Health Study WNYHS to test this hypothesis. From 1994 to 2000, 2,158 men, randomly selected from the general population of Erie and Niagara Counties, participated in the WNYHS. At recruitment, information on lifestyle factors and anthropometric characteristics were collected together with a sample of blood and urine. After an average follow-up period of four years, we expect to observe 151 incident prostate cancer cases arising from the cohort. A total number of 604 control subjects four for each prostate cancer case will be identified and matched for age, race and recruitment period with the related prostate cancer cases.
APPROVED FOR PUBLIC RELEASE