A Comparison of the Effects of Preemptive Oral Dextromethorphan on Perceived Postoperative Pain in Male and Female Patients Undergoing Arthroscopic Knee surgery
Final rept. Dec 2002-Nov 2003
TEXAS UNIV HEALTH SCIENCE CENTER AT HOUSTON SCHOOL OF NURSING
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Postoperative pain leads to increased morbidity, length of stay, and health care costs. Several studies have shown that preemptively administered N-methyl-D-aspartate NMDA antagonists, such as ketimine, are effective in decreasing perception of postoperative pain. To date, there have not been any human studies to investigate a gender difference m NMDA receptor antagonism. The purpose of this study was to compare the gender differences in the effects of preemptive ketimine on perceived pain in males and females undergoing selected ENT surgical procedures. This prospective, double-blinded study compared perceived pain in male and female subjects drawn from a convenience sample of patients at a major military medical center. The surgeries there patients were presenting for were tonsillectomy, adenoidectomy, tonsillectomy and adenoidectomy TA and uvulopalatopharyngoplasty UPPP. 41 subjects were randomly assigned to either a treatment group receiving . lmgkg ketimine or a control group receiving a placebo of .9 saline. The study drug was administered between induction and incision. Pain perception following surgery was measured using a Numeric Rating Scale NRS on arrival to the post anesthesia care unit PACU, and at four subsequent data points 1, 4, 12, 24 hours after PACU arrival time. ANOVA and Friedman tests were used to analyze the NRS scores. The ANOVA test did not show a significant difference p .768 in postoperative pain perception between males and females who received preemptive ketimine. The Friedman test did not show a significant difference p .27 in the level of postoperative pain perception within the groups over the five data collection points.
- Anatomy and Physiology
- Medicine and Medical Research