Modifiers of the Efficacy of Risk-Reducing Salpingo-Oophorectomy for the Prevention of Breast and Ovarian Cancer in Carriers of BRCA1 and BRCA2 Mutations
Annual summary rept. 1 May 2003-30 Apr 2004
MEMORIAL SLOAN-KETTERING CANCER CENTER NEW YORK
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The principal investigator was funded via a Physician-Scientist Training Award to participate in a comprehensive training plan to foster the transition to independent clinical breast cancer researcher. This plan included 1 conduct of a prospective study examining modifiers of the efficacy of risk-reducing salpingo-oophorectomy for the prevention of breast and ovarian cancer in carriers of BRCA mutations and 2 participation in coursework in research methodology, biostatistics, molecular biology, and ethics. Progress from 512003 - 4302004 includes 1 Accrual at a greater than expected rate to the planned research study 2 Participation in a clinical cancer research methods course with production of a new research proposal for the Gynecologic Oncology Group 3 Co-authored manuscript examining prostate cancer risk of men with BRCA mutations and 4 Conducted a pilot study suggesting that women from BRCA-negative hereditary breast cancer families are not at increased risk for ovarian cancer.
- Anatomy and Physiology
- Medicine and Medical Research