A Comparison of Gender Differences in the Effects of Preemptive Ketamine on Percieved Pain in Males and Females Undergoing Selected Ear, Nose, and Throat Surgical Procedures
Final rept. Nov 2002-Oct 2003
TEXAS UNIV HEALTH SCIENCE CENTER AT HOUSTON
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Postoperative pain leads to increased morbidity, length of stay, and health care costs. Several studies have shown that preemptively administered N-methyl-D-aspartate NMDA antagonists, such as ketamine, are effective in decreasing perception of post operative pain. To date, there have not been any human studies to investigate a gender difference in NMDA receptor antagoism. The purpose of this study was to compare the gender differences in the effects of preemptive ketamine on perceived pain in males and females undergoing selected ENT surgical procedures. This prospective, double-blinded study compared perceived pain in male and female subjects drawn from a convenience sample of patients at a major military medical center. The surgeries there patients were presenting for were tonsillectomy, adenoidectomy, tonsillectomy and adenoidectomy TA and uvulopalatoparyngoplasty UPPP. 41 subjects were randomly assigned to either a treatment group receiving .lmgkg ketamine or a control group receiving a placebo of .9 saline. The study drug was administered between induction and incision. Pain perception following surgery was measured using a Numeric Rating Scale NRS on arrival to the post anesthesia care unit PACU, and at four subsequent data points 1, 4, 12, 24 hours after PACU arrival time. ANOVA and Friedman tests were used to analyze the NRS scores. The ANOVA test did not show a significant difference p .768 in postoperative pain perception between males and females who received preemptive ketamine. The Friedman test did not show a significant difference p .27 in the level of postoperative pain perception within the groups over the five data data collection points.
- Medicine and Medical Research