Accession Number:

ADA426268

Title:

Proteomic Analysis to Identify Novel Circulating Breast Cancer Markers

Descriptive Note:

Annual rept. 27 May 2003-26 May 2004

Corporate Author:

M D ANDERSON CANCER CENTER HOUSTON TX

Personal Author(s):

Report Date:

2004-06-01

Pagination or Media Count:

4.0

Abstract:

The purpose of our proposed work is to study differences in serum protein expression profiles between healthy women and women with breast cancer, and to discover novel tumor markers. We intend to generate proteomics spectra on serum samples from 100 healthy women and 100 breast cancer patients. The goal of this analysis is to identify serum proteomic patterns using a matrix-assisted laser desorption ionisation that can distinguish women with breast cancer from healthy women. The origin and full identity of the discriminating proteins or peptides will be investigated. The protocol is under review by the Office of Regulatory Compliance and Quality at U.S. Army Medical Research and Materiel Command. I received their first review of the protocol and informed consent on January 21, 2004, and replied to their comments and concerns on January 30, 2004. I received a second review with additional comments on June 1, 2004 and I replied on June 10, 2004. I am still waiting for the final approval of the protocol and informed consent. I was informed that I cant initiate this study until 1 receive approval through the USAMRAA Contracting Office. Therefore, I have no results to report at the present time.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE