Accession Number:

ADA426112

Title:

Ultra Short Pulse Electroporative Physics and Technology

Descriptive Note:

Final technical rept. 1 Aug 2003-31 Jul 2004

Corporate Author:

UNIVERSITY OF SOUTHERN CALIFORNIA LOS ANGELES DEPT OF ELECTRICAL ENGINEERINGAND ELECTROPHYSICS

Personal Author(s):

Report Date:

2004-08-01

Pagination or Media Count:

9.0

Abstract:

The project has demonstrated that ultra-short, high-field pulses are a useful tool for study of cellular physiology, and a potential therapeutic instrument for malignant cells. The research has established that intracellular effects including apoptosis can be induced by the application of short, intense but low total energy electric pulses. Experiments on human cells have produced convincing evidence that these applied fields nondestructively alter subcellular processes and can be investigated using biophotonic studies for imaging of morphological and functional changes at subcellular levels. The results suggest a promising pathway toward achieving the ultimate goal of selectively disabling tumor or other undesirable cells. In addition to demonstrating that ultrashort pulses have potentially important applications for cell and cancer biology investigations, and for understanding the application of pulsed fields to living matter, these results demonstrate that an effective and productive multidisciplinary collaboration between science, engineering, medicine and biology has been created. nanosecond high-field electric pulse electrnpenturbaUon, electroporation, pulse-Induced phospholipid translocation, nanoelecfropuls

Subject Categories:

  • Biochemistry
  • Genetic Engineering and Molecular Biology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE