Drug Development and Conservation of Biodiversity in West and Central Africa
Final rept. 1 May 1999-30 Apr 2004
PACE UNIV NEW YORK NY
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This is the final report of associated project AP 3 of the International Cooperative Biodiversity Group ICBG Program, which was headed by the Walter Reed Army Institute for Research WRAIR. The project involves screening extracts of medicinal plants from Central and West Africa for growth-inhibitory activity vs. human and veterinary pathogenic African trypanosomes and trichomonads. Both drug-sensitive and drug-refractory isolates of each group were used. During this period approximately 281 extracts were received from WRAIR and the University of Dschang, Cameroon AP 2. Approximately 2600 individual as says were done for trypanosomes to obtain ICsub 50 values or growth inhibition data for 253 extracts. An additional 47 extracts were screened vs. trichomonads, comprising 300 assays, and minimal inhibitory concentration MIC values obtained for all with at least one isolate. Forty-two extracts had ICSUB 50 values of 1.0 microngramml for trypanosomes, and 38 had MIC values of 0.6 mgml for one or more of the trichomonad isolates. Some of the plant genera providing highly active material vs. trypanosomes were Premma, Cassia, Guarea, Melian, Goyania, Culcasis, Hyptis, Cassytha, Holarrhena , Jatropha, Combretum, Renealima, Boerrhavia and Etythrina. Among the most active extracts vs. trichomonads were those from Aspilia, Combretum, Enantia, Hoslundia, Mormodica, Phyllanthus, Cleistopholis, Mitracarpus, and Draecaena.
- Medicine and Medical Research