Dynamic Modeling and Control in PBPK Models for Toxic Agents Electromagnetic Imaging and Active Stealth
Final rept. 1 Dec 2000-31 Mar 2004
NORTH CAROLINA STATE UNIV AT RALEIGH CENTER FOR RESEARCH IN SCIENTIFIC COMPUTATION
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This project had three major objectives i the development or an inverse problem methodology theoretical, statistical and computational for parameter estimation in the presence of model and data uncertainty. Applications investigated include tissue dissipation of electromagnetic pulsed waves and molecular based models for polymers ii the development of electromagnetic interrogation and anti-interrogation active stealth methodologies. This includes research on use of moving acoustic interfaces as virtual mirrors to reflect electromagnetic interrogation signals, development of polarization models to characterize complex composite materials, and development of stealth methodologies in an electromagnetic pursuitevasion two player, min-max game theoretic framework. and iii development of molecular based models for hysteresis in polymers and models for electromagneticpolymeric interactions. Triehloroethylenc TCE is a solvent that has been widely used in government e.g.,USAF and industrial projects as a metal-decreasing agent, and is now a common soil and groundwater contaminant. Numerous studies have linked TCE and several of its metabolites to short-term toxic health effects such as headaches, dizziness and drowsiness, as well as long-term effects including kidney, liver and lung tumors see L.TCE is highly soluble in lipids, and is known to accumulate in the adipose fat tissue of hurnans and animals. This important characteristic of TCE has major implications on its dynamics inside the organs and tissues, and on the overall amount of time it takes for TCE to be eliminated from the body. Physiologically based pharmacokinetic PBPK models are used in the field of toxicology to describe the systemic transport behavior of compounds such as TCE.
- Statistics and Probability
- Electricity and Magnetism
- Electromagnetic Pulses