Evaluation of Response to Induction Therapy in Breast Cancer With Phosphorus-31 Magnetic Resonance Spectroscopy
Final rept. 10 Jun 2000-9 Jul 2003
MASSACHUSETTS GENERAL HOSPITAL BOSTON
Pagination or Media Count:
The objective of the proposed research is to develop 1H-decoupled 31P magnetic resonance spectroscopy MRS techniques for measuring non-invasively the response of breast cancer to induction or preoperative chemotherapy. We hypothesize that the quantitative assessment of the effectiveness of a treatment using 31P MRS will be clinically feasible at 3.OT. Although the hardware modifications made to the MR scanner to enable 31P MRS were completed, and a breast RF coil was constructed and tested successfully, significant delays in the delivery of the scanner and in the manufacturer providing scanner software to properly operate at the phosphorus frequency resulted in poor progress. Patient scanning was not achieved. It is expected that some patients will be scanned in the near future using another source of funding in order to complete the goals of the study.
- Anatomy and Physiology
- Medicine and Medical Research
- Atomic and Molecular Physics and Spectroscopy