Accession Number:

ADA426050

Title:

The Role of N-Cadherin in Breast Cancer Metastasis

Descriptive Note:

Annual summary 1 May 1999-1 May 2004

Corporate Author:

MOUNT SINAI SCHOOL OF MEDICINE NEW YORK

Personal Author(s):

Report Date:

2004-06-01

Pagination or Media Count:

11.0

Abstract:

The intracellular signaling events that cause tumor cells to become metastatic are not well understood. N-cadherin and FGF-2 synergistically increase migration, invasion and secretion of extracellular proteases in breast tumor cells. Here, we define a metastatic signaling cascade activated by N-cadherin and FGF-2. In the presence of N-cadherin, FGF-2 MAPK-ERK pathway, leading to MMP-9 gene transcription and cellular invasion.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE