Accession Number:

ADA424561

Title:

Regulation of Apoptosis in Breast Cancer by NF-KappaB and IAB Axis

Descriptive Note:

Annaual summary rept. 1 Jul 2002-30 Jun 2003

Corporate Author:

BURNHAM INST LA JOLLA CA

Personal Author(s):

Report Date:

2003-07-01

Pagination or Media Count:

28.0

Abstract:

Defects in apoptosis contribute to the pathogenesis and progression of breast cancer. One of the modulators of apoptosis is NF-KappaB, a family of heterodimeric transcription factors containing a conserved REL homology domain. Apoptosis relevant targets of NF-KappaB include Bfl-1, bcl-Xsub L, FLIP, cIAP2, and others. We sought to identify novel regulators of NF-KappaB. We identified novel members of a family of PAADPYRIN domain-containing proteins, called PAs2 and NAC. These proteins modulate activity of the I-KappaB kinases IKKs. Discovery of these novel NF-KappaB regulators provides new insights into mechanisms of apoptosis regulation and also may be of relevance to immune responses to breast cancers.

Descriptors:

• *PROTEINS
• *GENETICS
• *BREAST CANCER
• *APOPTOSIS
• BIOLOGY
• HUMANS
• THERAPY
• GENES
• RESPONSE(BIOLOGY)
• INHIBITORS
• DEATH
• CELLS(BIOLOGY)
• WOMEN
• PATHOGENESIS
• ABNORMALITIES
• CHEMOTHERAPEUTIC AGENTS
• PHOSPHORUS TRANSFERASES
• TRANSCRIPTION(GENETICS)

Subject Categories:

• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE