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Accession Number:
ADA423288
Title:
Neuroprotection from Brain Injury by Novel Estrogens
Descriptive Note:
Annual rept. 1 Aug 2000-31 Jul 2001
Corporate Author:
UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER FORT WORTH TX
Report Date:
2001-08-01
Pagination or Media Count:
176.0
Abstract:
The present program of research aims at determining the neuroprotective activity of novel estrogens in both male and female animal models for brain ischemic damage. We have proposed to achieve 4 technical aims over the course of 3 years. These aims relate to a description of the activity of several estrogens against cerebral damage related to middle cerebral artery occlusion in a rodent model, when the estrogens are administered prior to or following the ischemic event. We also are pursuing our observation that androgen reduction is neuroprotective in male subjects. We will assess during years 2 and 3 of the grant the potential mechanisms of the neuroprotective activity of estrogens and of androgen reduction in these models by determining the extent to which estrogens or androgen reduction reduce oxidative damage associated with stroke and then assess the involvement of signal transduction processes and anti-apoptotic proteins in the neuroprotective activity of estrogens. Collectively, these studies will provide the knowledge needed to determine if estrogen therapy and androgen reduction therapy are usefil in protection of the brain tissue from damage related to the activities of U.S. Army male and female personnel.
Distribution Statement:
APPROVED FOR PUBLIC RELEASE
