Synthetic Lethality in Breast Cancer Cells: Genes Required for Tumor Survival
Annual rept. 1 Jun 2002-1 Jun 2003
COLD SPRING HARBOR LAB NY
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The conversion of a normal cell into a cancer cell proceeds through a series of genetic and epigenetic alterations. We have proposed to use well-established genetic methodologies to identify novel anti-cancer targets via their specific, genetic interactions with common cancer mutations. In short, we will identify genetic alterations that are neutral in normal cells, but that are lethal when combined with cancer mutations. This synthetic lethality approach may identify potential therapeutic targets that are highly specific to the cancer cell. In the past year, we have created tools that will permit such screens to be undertaken for the first time in mammalian cells and have validated those tools in a model genetic screen.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research