Enhanced T Cell Attack of Brain Micro-Metastases
Annual rept. 1 Jul 2002-30 Jun 2003
BRIGHAM AND WOMEN'S HOSPITAL BOSTON MA
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Brain-metastasizing breast cancer is a major clinical problem. Cell-mediated immuno- therapy is well-suited to attack it, but the efficacy must be increased. Our work addresses two basic research problems A The need for appropriate small animal models for blood-borne brain metastases, and B the need for greater basic understanding of immune modulation in the brain. In year 1, we reported initial characterization of a novel rat model. In year 2, we reported identification, analysis, and solutions for a series of technical problems. Now, in year 3, we report A Further work in the tumor model, including 1 Methods for quantitative analysis and depiction of micro-tumor distribution, 2 the distribution of blood-borne micro-metastases in untreated control rats, 3 provocative evidence that a simple needle wound can change the distribution S Further work on our proposed immunotherapy injection of gamma interferon IFN-g, including 1, New basic findings on immune modulation and delivery routes, 2 our approach to further probing the functional consequences of attempted immunotherapy C Related efforts, including a comprehensive special issue of the Journal of Neuro-Oncology on Brain Tumor Immunotherapy, co-edited and with an introductory overview by the PI.
- Anatomy and Physiology
- Medicine and Medical Research