Phase I Induction and Estrogen Metabolism in Women with and Without Breast Cancer and in Response to a Dietary Intervention
Annual rept. 30 Sep 2002-29 Sep 2003
SOUTH CAROLINA UNIV COLUMBIA
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The combined case-comparison study and randomized controlled trial RCT of 90 women is based on our prior edpidemiologic work 1-6 indicating that vegetables in the Brassica genus e.g., broccoli, cauliflower, brussel sprouts can modify estrogen metabolism by causing l7beta- estradiol E2 to be metabolized to 2-hydroxyestrone 2HE rather than 16alpha-hydroxyestrone l6HE thus producing a cascade of effects protective against breast cancer 2. Our plan is to enroll 45 postmenopausal women with breast cancer and 45 age-matched disease-free women and to compare them on 1 AhR activation and its various protein products relevant to cancer including CYPlBl, PAZ- 2, and IL-l and 2 levels of relevant estrogens-, E2, 2HE, and l6HE. The RCT will examine the effect of an intensive Brassica-rich diet intervention on AhR activation, its protein products, and estrogen metabolites in these women. This study is completing its third year of no-cost activity. All protocols for the collection of data are finalized and we have recruited 83 participants. The baseline data have been collected for case-comparison study and the last intervention cycle for the RCT will be in September 2003.
- Medicine and Medical Research
- Food, Food Service and Nutrition