Accession Number:

ADA422949

Title:

A Population-Based Investigation of the Role of Focal Adhesion Kinase (FAK) and E-Cadherin Expression in Breast Cancer Promotion, Progression and Therapeutic Response

Descriptive Note:

Annual summary rept. 1 Oct 2002-30 Sep 2003

Corporate Author:

NORTH CAROLINA UNIV AT CHAPEL HILL

Personal Author(s):

Report Date:

2003-10-01

Pagination or Media Count:

9.0

Abstract:

Presented within this annual report are the details of the second years progress and the preliminary results of the grant entitled A population based investigation of the role of Focal Adhesion Kinase FAK and E-cadherin expression in breast cancer promotion, progression, and therapeutic response. In regards to the specific aims of the grant, immunohistochemical staining has been completed for both FAK and E-cadherin expression. Scoring has been completed on all 629 samples stained for FAK, providing information regarding the prevalence and pattern of FAK expression as well as its association with other known risk and prognostic factors for breast cancer. Scoring has been completed on all sample for E-cadherin following the development of a more-comprehensive scoring system. Collection of survival data is ongoing. Completing the proposed aims should elucidate the role of FAK and E-cadherin expression as a verifiable marker of disease aggressiveness, and will provide a better understanding of the biological behavior thus allowing for a more tailored treatment of breast cancer.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE