Accession Number:

ADA422770

Title:

Alteration of the Endothelial Barrier by Breast Cancer Cells as a Mechanism of Tumor Resistance

Descriptive Note:

Final rept. 1 May 2001-30 Apr 2002

Corporate Author:

OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS

Personal Author(s):

Report Date:

2002-05-01

Pagination or Media Count:

8.0

Abstract:

The endothelial cells lining blood vessels that perfuse breast tumors present a barrier that antineoplastic agents must cross to reach the tumor cells. The purpose of this award was to provide preliminary data to support the hypothesis that tumor cells can modulate this barrier by secreting soluble factors, by affecting extracellular matrix, or by a combination of these factors. The specific aims of this project were to 1 determine tumor cell induced expression of multi-drug-resistance proteins in endothelial cells and 2 determine tumor cell mediated changes in Adriamycin transport across endothelial cells. Experiments performed to address aim 1 revealed no tumor mediated increases in p-gp protein a classic multi-drug resistance protein in endothelial cells.

Subject Categories:

  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE