Accession Number:

ADA422762

Title:

Increasing Oxygen Consumption During Shock

Descriptive Note:

Final rept. 1 Jan 1995-30 Apr 2004

Corporate Author:

VIRGINIA UNIV CHARLOTTESVILLE DEPT OF CHEMICAL ENGINEERING

Personal Author(s):

Report Date:

2004-05-04

Pagination or Media Count:

9.0

Abstract:

Whole-body oxygen consumption is decreased after hemorrhage. Typical methods for increasing oxygen consumption have involved increasing the blood oxygen concentration using enriched oxygen gases, hemoglobins and fluorocarbon compounds however, clinical trials involving these have not been totally successful. Increasing the oxygen concentration increases its diffusion rate through blood plasma however, an alternative method would be to increase the diffusion coefficient of oxygen itself. This was shown to be possible using a naturally-occurring compound called crocetin. Crocetin also increased whole-body oxygen consumption in hemorrhaged rats and resulted in an increased survival rate. However, this occurred over a relatively small concentration range. Thus, trans sodium crocetinate TSC was developed, which also increases oxygen consumption in rats after hemorrhage and increases survival. TSC has also been shown to increase blood pressure and to reduce the acidosis that forms with hypoxia and to reduce damage to liver and kidney.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE