Low Level Chemical Toxicity: Relevance to Chemical Agent Defense
Annual rept. 23 Jun 2002-2 Jun 2003
WRIGHT STATE UNIV DAYTON OH
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A multidisciplinary project is underway to study the influence of low-level exposure to chemicals to which military personnel had contact during the Persian Gulf War. The research group includes investigator with expertise in neuroscience, molecular biology, enzymology, cardiovascular physiology and neuropharmacology. The overall objectives is to study the effect of chemical exposure from the single cellgene level to the whole animal and ending with the human condition. Results include but are not limited to proteomic changes have been identified that are different between pyridostigmine bromide and physostigmine spectral analysis has showed dramatic alterations in heart rate variability and baroreflex index in mice challenged with stress andor pyridostigmine sarin and noise stress and also pyridostigmine bromide and DEET with noise stress induce significant decreases in electron transfer rates compared to noise stress alone, factors have been identified which will increase the reliability of correlations between enzymatic analyses and abnormal or disease states modest gene expression changes have been determined using Mann- Whitney tests after eliminating those genes with expression levels that appear to represent inactive genes.
- Medicine and Medical Research
- Chemical, Biological and Radiological Warfare