Effects of Moderate Aerobic Exercise Combined with Caloric Restriction on Circulating Estrogens and IGF-I in Premenopausal Women
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PENNSYLVANIA STATE UNIV STATE COLLEGE
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The proposal entitled Effects of moderate aerobic exercise combined with caloric restriction on circulating estrogens and IGF-I in premenopausal women will provide important scientific contributions with respect to the primary prevention of breast cancer in women. Specifically, this study will examine potential mechanisms relating to the role of physical activity in the reduction of the risk of breast cancer by testing whether moderate aerobic exercise can reduce the levels of two hormonal biomarkers, circulating estrogens and insulin-like growth factor I IGF-I. as expected caloric restriction combined with aerobic exercise training occurring 4 times per week has resulted in increases in aerobic capacity, weight loss ranging from 2.5-7.5 kg and loss of body fat raging form 3 to 7 over four months. Results for T3, IGF-1, and estrone look promising, although the number of subjects who have completed the study thus far is too low to test these changes statistically. Compliance to our dietary and exercise protocols has been excellent, with subjects completed 3.84 workouts per week, and meeting or exceeding their caloric intake goals. In conclusion, we are making good progress toward completion of this study.
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- Medicine and Medical Research