Accession Number:

ADA422532

Title:

Quantitative Characterization of Pulmonary Pressure-Volume Curve for Improved Care of Acute Lung Injury

Descriptive Note:

Annual rept. 1 Mar 2002-28 Feb 2003

Corporate Author:

NORTHEASTERN UNIV BOSTON MA

Personal Author(s):

Report Date:

2003-03-01

Pagination or Media Count:

108.0

Abstract:

Continuous sigmoidal tangent-hyperbolic and error-function p-V model equations with four parameters are shown to represent clinical p-V curves accurately. The magnitudes of the four parameters, coupled with the normalized p-V equation, distinguish p-V data sets effectively. A mechanistic model of the total respiratory system is developed for the inflation process, relating characteristics of the p-V model equation to the internal respiratory conditions such as alveolar recruitment and elastic distension of tissues. The model is based on the principle of statistical mechanics applied to the total respiratory system as an ensemble of a large number of respiratory elements, each of which consists of a piston-spring subsystem. The ability of the mechanistic model to predict volume limits of the corresponding deflation process justifies its theoretical foundation.

Subject Categories:

  • Anatomy and Physiology
  • Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE