Accession Number:

ADA422418

Title:

Role of Heregulin in the Neovascularization of Breast Carcinoma Cancer

Descriptive Note:

Annual summary rept. 1 Aug 2002-31 Jul 2003

Corporate Author:

EVANSTON NORTHWESTERN HEALTHCARE RESEARCH INST IL

Personal Author(s):

Report Date:

2003-08-01

Pagination or Media Count:

47.0

Abstract:

Several oncogenes, growth factors, hormones and hypoxia have been shown to up-regulate Vascular Endothelial Growth Factor VEGF, an essential angiogenic factor for the progression of breast carcinomas. We previously demonstrated that he angiogenic factor CCN1 CYR61, a member of the CCN family of growth regulators, is differentially expressed in breast cancer cells overexpressing Heregulin HRG, a member of the epidermal growth factor-like growth factor family that regulates angiogenesis via up-regulation of VEGF expression and secretion. More recently, we found that CCN1- induced tumors in ovariectomized athymic nude mice did resemble human invasive carcinomas with increased vascularization and overexpression of VEGF.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE