Accession Number:

ADA422402

Title:

EphA2 Kinase Agonists as Novel Suppressors of Both Prostate Cancer Cell Motility and Growth: Structure-Function Relations and the Role of RAS/MPK Pathway

Descriptive Note:

Annual rept., Phase 3, 1 Sep 2002-31 Aug 2003

Corporate Author:

CASE WESTERN RESERVE UNIV CLEVELAND OH

Personal Author(s):

Report Date:

2003-09-01

Pagination or Media Count:

54.0

Abstract:

There are three goals in this proposal. 1 To establish the expression profile of EphA2 during TRAMP prostate cancer development and progression, which will help determine the optimal window of EphA2 targeting. 2 To target EphA2 with its native and artificial agonists to see if they can suppress TRAMP prostate cancer development andor progression. 3 To investigate the role of EphA2 during prostate cancer development by crossing EphA2- null mice with TRAMP mice. During the past 6 months since this modified grant was reactivated, we have made significant progress breeding and genotyping large number of animals required for achieving the goals.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE