EphA2 Kinase Agonists as Novel Suppressors of Both Prostate Cancer Cell Motility and Growth: Structure-Function Relations and the Role of RAS/MPK Pathway
Annual rept., Phase 3, 1 Sep 2002-31 Aug 2003
CASE WESTERN RESERVE UNIV CLEVELAND OH
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There are three goals in this proposal. 1 To establish the expression profile of EphA2 during TRAMP prostate cancer development and progression, which will help determine the optimal window of EphA2 targeting. 2 To target EphA2 with its native and artificial agonists to see if they can suppress TRAMP prostate cancer development andor progression. 3 To investigate the role of EphA2 during prostate cancer development by crossing EphA2- null mice with TRAMP mice. During the past 6 months since this modified grant was reactivated, we have made significant progress breeding and genotyping large number of animals required for achieving the goals.
- Anatomy and Physiology
- Medicine and Medical Research