Enhancing the Immune Response to Recombinant Plague Antigens
Annual rept. 20 Sep 2002-19 Sep 2003
TULANE UNIV HEALTH SCIENCE CENTER NEW ORLEANS LA
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The etiologic agent of plague is the Gram negative bacterium Yersinia pestis. Y. pestis is a concern as one of the microorganisms with potential for use against civilian or military populations as a biological warfarebiological terrorism agent. In that case, the pneumonic form of plague would be the most likely outcome. This form of plague is particularly devastating because of the rapidity of onset, the high mortality, and the rapid spread of the disease. Immunization against aerosolized,plague presents a particular challenge for vaccine developers. The studies reported herein explore the ability of a novel adjuvant, designated LT R192G, to promote the rapid development of long-lasting, high titer antibodies against a recombinant plague antigen Fl-v in a murine model. Subsequent studies will be performed in non-human primates. Different routes of administration are examined to test the hypothesis that heterologous boosting will be more effective than homologous boosting at increasing the magnitude andor duration of the antibody response.
- Medicine and Medical Research