Genetic Definition and Phenotypic Determinants of Human Ovarian Carcinomas
Final addendum rept. 1 Oct 2002-30 Sep 2003
CALIFORNIA UNIV LOS ANGELES
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Ovarian cancer is the fourth leading cause of cancer-related death in U.S. women. This program project approaches the ovarian cancer problem by 1 establishing a human ovarian tissue and clinical data base core facility to support the proposed projects and future investigations, 2 identifying genes which are differentially expressed in ovarian cancers and thereby discovering biomarkers for early detection, 3 studying ovarian tumorigenesis in ovarian tissues obtained from germ line BRCA1 mutation carrier to better understand the interaction between mutational inactivation of BRCA1, the cellular caretaker gene and p53, the cellular gatekeeper gene, and 4 developing a genetically defined mouse model of epithelial ovarian cancer.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research