Accession Number:

ADA422209

Title:

Center for the Evaluation of Biomarkers for the Early Detection of Breast Cancer

Descriptive Note:

Annual rept. 23 Sep 2002-22 Sep 2003

Corporate Author:

FRED HUTCHINSON CANCER RESEARCH CENTERSEATTLE WA

Personal Author(s):

Report Date:

2003-10-01

Pagination or Media Count:

118.0

Abstract:

Breast cancer remains a leading cause of death for women in the U.S. despite the popularity of mammography as a preventive tool. At diagnosis, many breast cancers are at an advanced stage of disease, even for women undergoing yearly screening, resulting in costly and painful follow-up procedures. Based on the ongoing studies in many research institutions, it has been shown that molecular markers can increase our ability to diagnose early stages tumors. This has been demonstrated by current clinical practices using the CA-125 marker and PSA for the detection of ovarian and prostate cancer, respectively. The purpose of this study is to search for breast cancer biomarkers and evaluate their effectiveness in detecting early stage carcinoma. By combining molecular diagnosis with current imaging analysis of breast tissue, we may further reduce the number of deaths as well as the number of women undergoing surgery and chemotherapy due to breast cancer. To date, we have created the infrastructure necessary for our interdisciplinary team of investigators to obtain study samples, characterize respective biomarkers, and efficiently communicate research findings. We have also increased the number of potential biomarkers and looked into more efficient and sensitive biotechnology that may better assist our study investigators.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE