Humanized Monoclonal Antibody Specific to the Extracellular Domain of PSMA: Dose Escalation Trial in Patients with Prostate Cancer
Final rept., Phase 2, 1 Jun 1998-30 Nov 2003
CORNELL UNIV MEDICAL COLL (WEILL) NEW YORK
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Prostate specific membrane antigen PSMA is the single most well-established, highly restricted prostate epithelial cell membrane antigen expressed by virtually all prostate cancers. PSMA is an ideal target for developing radio labeled monoclonal antibodies mAbs for radioimmunotherapy RIT of prostate cancer. J591 mAb binds with very high affinity to the extra-cellular domain of PSMA and binds to viable tumor cells. We have previously submitted the final report of the Phase I of the Idea development Award in November 2000.
- Medicine and Medical Research