Accession Number:

ADA422002

Title:

Humanized Monoclonal Antibody Specific to the Extracellular Domain of PSMA: Dose Escalation Trial in Patients with Prostate Cancer

Descriptive Note:

Final rept., Phase 2, 1 Jun 1998-30 Nov 2003

Corporate Author:

CORNELL UNIV MEDICAL COLL (WEILL) NEW YORK

Personal Author(s):

Report Date:

2003-12-01

Pagination or Media Count:

46.0

Abstract:

Prostate specific membrane antigen PSMA is the single most well-established, highly restricted prostate epithelial cell membrane antigen expressed by virtually all prostate cancers. PSMA is an ideal target for developing radio labeled monoclonal antibodies mAbs for radioimmunotherapy RIT of prostate cancer. J591 mAb binds with very high affinity to the extra-cellular domain of PSMA and binds to viable tumor cells. We have previously submitted the final report of the Phase I of the Idea development Award in November 2000.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE