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Preparation of a Burkholderia Mallei Vaccine

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Final addendum rept. 31 Jan-31 Dec 2003

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Since Burkholderia mallie is of significance as an agent of bioterrorism Category B, Centers for Disease Control, U.S. and biological warfare, the development of effective vaccines and treatments is of particular concern. Our understanding of the disease caused by this organism is rapidly emerging, and we must move forward with our studies on the pathogenesis of this disease in order to develop new and effective vaccines andor therapies against this organism. There is considerable dual use potential, since the development of vaccines and treatments can provide important items to assist the World Health Organization, to assist in providing a state of preparedness in case of bioterrorism attacks and to assist signatories of the Biological and Toxin Weapons Convention under Article X of the Convention. The long-term objective of our research is to define at a molecular level the pathogenesis of disease due to Burkholderia ssp. My laboratory is recognized internationally as a world leader in the understanding of the pathogenesis of disease caused by Burkholderia ssp., and considerable advances in understanding of the diseases caused by these organisms have already been made by my laboratory.

Subject Categories:

  • Medicine and Medical Research
  • Pharmacology
  • Chemical, Biological and Radiological Warfare
  • Unconventional Warfare

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