Accession Number:

ADA416888

Title:

Effect of Angiogenic Growth on Tumor Growth, Vascular Function, and the Development of Hypoxic Therapeutic Resistance

Descriptive Note:

Final rept. 1 May 2002-30 Apr 2003

Corporate Author:

ROCHESTER UNIV NY

Personal Author(s):

Report Date:

2003-05-01

Pagination or Media Count:

188.0

Abstract:

The primary objectives of this grant were to determine the effects of either angiogenic growth factor overexpression or inhibition on mammary tumor pathophysiology. We evaluated four transfected human breast tumors and two murine mammary carcinoma lines by developing new methods for image analysis to quantify tumor vascular structure and function as well as micro-regional hypoxia. A particular emphasis was the comparison of several antiangiogenic strategies, including endostatin, anti-VEGFR-2, and Celebrex, to quantitate the pathophysiological response to each.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE