Genetic and Epigenetic Mechanisms Underlying Acute and Delayed Neurodegenerative Consequences of Stress and Anticholinesterase Exposure
Annual rept. 15 Jul 2000-14 Jul 2001
HEBREW UNIV JERUSALEM (ISRAEL)
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We have observed the role of the stress-associated acetylcholinesterase variant, AChE-R in several model systems. In AChE transgenic mice, the neuronal overexpression of AChE-R is associated with behavioral impairments. In another animal model, the honey bee, developmental reduction of ache gene expression paralleled their normal, consistent improvement of behavioral functions, and experimental improvement under mild rivastigmine exposure.
- Stress Physiology