Accession Number:

ADA416887

Title:

Genetic and Epigenetic Mechanisms Underlying Acute and Delayed Neurodegenerative Consequences of Stress and Anticholinesterase Exposure

Descriptive Note:

Annual rept. 15 Jul 2000-14 Jul 2001

Corporate Author:

HEBREW UNIV JERUSALEM (ISRAEL)

Personal Author(s):

Report Date:

2001-08-01

Pagination or Media Count:

296.0

Abstract:

We have observed the role of the stress-associated acetylcholinesterase variant, AChE-R in several model systems. In AChE transgenic mice, the neuronal overexpression of AChE-R is associated with behavioral impairments. In another animal model, the honey bee, developmental reduction of ache gene expression paralleled their normal, consistent improvement of behavioral functions, and experimental improvement under mild rivastigmine exposure.

Subject Categories:

  • Biochemistry
  • Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE