Breast Cancer Screening Using Photonic Technology
Final rept. 15 Aug 1998-14 Feb 2003
CITY UNIV OF NEW YORK RESEARCH FOUNDATION
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The research carried out on this project was aimed at developing noninvasive optical detection and diagnostic methods for breast cancer. The approaches that were developed and pursued include a time-sliced near-infrared NIR two dimensional 2-D transillumination imaging for direct imaging of tumors, and generating data with robust information content for 3-D image reconstruction b spectroscopic 2-D NIR transillumination imaging for exploring the diagnostic potential of optical approach c derivation of analytical solutions of radiative transport equation RTE and development of inversion algorithms for reconstruction of 3-D tomographic images using a sequence of time-sliced 2-D images. Results of direct imaging measurements on ex vivo tumor and normal tissues were compared with biopsy, pathology, and nuclear magnetic resonance results for validation. Images recorded with earlier temporal slices of transmitted light were found to highlight cancerous tissues while those recorded with later slices accentuated normal fibrous tissues. Spectroscopic imaging experiments show that the ratio, R of light intensity transmitted through the cancerous tissue to that through the corresponding normal tissue exhibit a wavelength dependent variation that has the potential to be used as a useful parameter for cancer identification. Analytical solutions of RTE enable more complete description of light transport through tissue and forward models based on these solutions promise more accurate and agile 3-D image reconstruction schemes.
- Medicine and Medical Research
- Nuclear Physics and Elementary Particle Physics