Molecular Determinants of Prostate Cancer Progression Across Race-Ethnicity
Annual rept. 15 Apr 2002-14 Apr 2003
UNIVERSITY OF SOUTHERN CALIFORNIA LOS ANGELES
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This Prostate Cancer Center Initiation grant has been designed to identify genetic and molecular markers of prostate cancer progression within and between racial ethnic groups African-Americans, Latinos, Whites, Japanese at substantially distinct underlying risk of prostate cancer. Our Epidemiology Core has obtained signed tissue releases from prostate cancer patients to date identified during follow-up of the HawaiiLos Angeles Multiethnic Cohort study and has procured 438 tissue samples to date 163 African-Americans, 163 Latinos, 74 Caucasians, and 38 Japanese. These have been processed histopathologically by Project C, which has completed immunohistochemical staining for COX-2, p27, and Caveolin-1 markers with analysis of additional markers ongoing. Project B, studying the androgen receptor AR gene in detail, has conducted functional studies to understand non-steroidal activation of AR signaling. Project A, studying the SRD5A2 gene in detail, has characterized a series of the somatic mutations identified in tumors to date using site directed mutagenesis assays.
- Anatomy and Physiology
- Medicine and Medical Research