Accession Number:

ADA416738

Title:

Molecular Determinants of Prostate Cancer Progression Across Race-Ethnicity

Descriptive Note:

Annual rept. 15 Apr 2002-14 Apr 2003

Corporate Author:

UNIVERSITY OF SOUTHERN CALIFORNIA LOS ANGELES

Report Date:

2003-05-01

Pagination or Media Count:

19.0

Abstract:

This Prostate Cancer Center Initiation grant has been designed to identify genetic and molecular markers of prostate cancer progression within and between racial ethnic groups African-Americans, Latinos, Whites, Japanese at substantially distinct underlying risk of prostate cancer. Our Epidemiology Core has obtained signed tissue releases from prostate cancer patients to date identified during follow-up of the HawaiiLos Angeles Multiethnic Cohort study and has procured 438 tissue samples to date 163 African-Americans, 163 Latinos, 74 Caucasians, and 38 Japanese. These have been processed histopathologically by Project C, which has completed immunohistochemical staining for COX-2, p27, and Caveolin-1 markers with analysis of additional markers ongoing. Project B, studying the androgen receptor AR gene in detail, has conducted functional studies to understand non-steroidal activation of AR signaling. Project A, studying the SRD5A2 gene in detail, has characterized a series of the somatic mutations identified in tumors to date using site directed mutagenesis assays.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE