Tumor Oxygen Dynamics as a Prognostic Indicator of Effective Antiangiogenic Therapy
Annual summary rept. 1 May 2001-30 Apr 2003
TEXAS UNIV AT DALLAS SOUTHWESTERN MEDICAL CENTER
Pagination or Media Count:
Tumor survival, growth and metastasis depend critically on the development of new blood vessels so called angiogenesis. One major goal of this project is to fully understand and precisely assess the dynamic changes in blood perfusion and oxygenation, both during normal growth and following anti-angiogenic therapy in diverse prostate tumors with differential characteristics, so that we may predict response and optimize the therapy. Applying non-invasive MRI techniques, we successfully detected differential vasculature and oxygenation among prostate tumor lines with different degrees of aggressiveness. The slower growing and well differentiated H and HI tumors are better vascularized and oxygenated than the fast growing and anaplastic AT1 and metastatic MAT-Lu tumors. These MRI data has been validated by histological studies and irradiation. The metronomic therapy significantly inhibited the AT1 tumor growth. The dynamic contrast enhanced DCE MRI was capable of detecting early changes in tumor vasculature cause by the metronomic treatment. Histological studies verified formation of dramatic central necrosis, increased apoptosis, and decreased vascular density and proliferating rate in the treated tumors. Good correlation of the MRI data with tumor growth delay suggested that the non-invasive MRI could predict anti-angiogenic treatment efficacy.
- Anatomy and Physiology
- Medicine and Medical Research