Dietary Phytoestrogens and Prostate Cancer Prevention
Annual rept. 15 Apr 2002-14 Apr 2003
MINNESOTA UNIV MINNEAPOLIS
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The main objective of this project is to evaluate the effects of soy phytoestrogen consumption on reproductive hormones and prostate tissue markers of cell proliferation and androgen action in men at high risk of prostate cancer. The hypothesis is that alteration of endogenous hormones is a mechanism by which soy phytoestrogens prevent prostate cancer. A randomized parallel arm study will be performed, in which 90 men at high risk of prostate cancer will be randomized to receive one of three dietary supplements for six months 1 soy powder containing phytoestrogens 2 phytoestrogen-free soy powder or 3 phytoestrogen-free milk powder. Urine and blood will be collected at 0, 3 and 6 months, for evaluation of prostate cancer risk factors, including serum hormones testosterone, dihydrotestosterone, androstenedione, dehydroepiandrosterone, estradiol, estrone, 3alpha, 17Beta-androstanediol glucuronide, sex hormone binding globulin and prostate specific antigen, as well as urinary estrogen and phytoestrogen metabolites. Before and after the intervention, prostate biops will be performed to evaluate prostate tissue expression of apoptosis TUNEL assay, Bax, Bcl-2, proliferation Ki67, PCNA and androgen receptor density. At this point, seven subjects have begun the feeding study and biological samples have been collected, processed and stored.
- Medicine and Medical Research