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Relationships Between IGF-1, IGF-Binding Proteins and Diet in African American and Caucasian Men

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Annual rept. 15 Dec 2001-14 Dec 2002

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The study aims to determine racial differences between insulin-like growth factor-1 lGF-1, insulin-like binding protein-1 IGFBP-2, insulin-like binding protein-3 IGFBP-3, prostate specific antigen PSA, testosterone, body mass index BMI, and diets high in calories, protein and fat. Specifically, the primary objectives are to 1 define racial differences in serum levels of free and total IGF-1, IGFBP-2, IGFBP-3, and testosterone. 2 Define how diet and BMI impact serum levels of IGF-1, IGFBP-2, IGFBP-3, testosterone, PSA in African American and Caucasian men. 3 Determine the association between serum levels of free and total IGF-1, IGFBP-2, IGFBP-3, testosterone, PSA, EMI, and specific nutrients. The proposed study will help to explain the increased risk of prostate cancer for African American men and the role of specific nutrients in influencing IGF-1 and IGF-binding protein concentrations. This report covers primarily patient accrual activities during the first and second year of the project. These activities include finalizing the clinical protocol, hiring and training of study personnel, reviewing clinical questionnaires to determine study eligibility, and determination of stored frozen samples for use. A total of 544 men were recruited to participate in the study. Approximately 1,294 assays have been analyzed for IGF-1, IGF-binding proteins and testosterone. A total of 300 men were stratified and randomized for the telephone interview. Of this number, 138 men agreed to be interviewed and completed the nutrition questionnaires.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

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