Accession Number:

ADA416687

Title:

Angiogenesis and Invasiveness in Prostate Cancer Detected With Spectral and Spatial Resolution MRI

Descriptive Note:

Annual rept. 24 Dec 2001-23 Dec 2002

Corporate Author:

CHICAGO UNIV IL

Personal Author(s):

Report Date:

2003-01-01

Pagination or Media Count:

7.0

Abstract:

The goal of this research is to use high spectral and spatial resolution HiSS MR imaging to improve images of human and murine prostate. Our work on the application of HiSS to improve anatomic and functional imaging was first described in a paper in Academic Radiology 1. Related work from this laboratory is presented in a number of other publications 2-9. Work from other laboratories shows that closely related methods also provide advantages for anatomic 10 and functional 11-14 MRI. This significant body of work provides support for the feasibility of ongoing experiments in this laboratory. Specifically, we expect to 1 improve separation of water and fat signals 2 increase image contrast 3 increase sensitivity to contrast agents and to local physiology - and as a result improve detection of suspicious lesions such as cancers and particularly delineation of tumor edges. We expect that this will increase the sensitivity and specificity of MR scans for prostate cancer. To achieve these goals our original statement of work is summarized as follows

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE